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In the search for alternative production methods, various key intermediates or derivatives, such as hydrogenobyrate (HBA) 6 , hydrogenobyrinate a, c - diamide (HBAD) 7 and hydrogenobyric acid (Hby) 8 , have been obtained from engineered Eschericia coli strains, from which the titer of HBAD and Hby were reported to be 2.94 mg/L and 2.95 mg/L, respectively

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Nevertheless, caution should be exercised in extrapolating the results of animal studies to humans, and further research is needed to determine the safety and efficacy of GH therapy in human populations (Table 2)