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l-Buthionine Sulfoximine (BSO) treatment of HEK293 cells

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in 1973 Strong Cu²⁺ affinity — coordinates copper(II) via the Gly-His-Lys amino acid sequence Studied in preclinical models examining extracellular matrix remodeling, fibroblast activity, and collagen-associated signaling Referenced in gene expression research involving over 4,000 human genes in laboratory settings Appears as distinctive blue-green powder due to copper(II) complexation — visually distinguishable from non-copper peptides Lyophilized format ensures stability and reproducibility across experimental runs Batch and lot identifiers on all labeling for full laboratory documentation compliance Research Background GHK-Cu was first identified in human plasma in 1973 by Loren Pickart, Ph.D., who noted its role as a liver cell growth factor