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Inhibition of NLRP3 inflammasome alleviates postoperative cognitive impairment by suppressing the HMGB-1/TLR4/NF-kappaB pathway
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This was confirmed in an additional cell line and with depletion of αKG or suppression of αKGDDs using knockdown/inhibition of IDH1, glutamine starvation, or succinate supplementation ( Fig
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