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Annexin A1, a central modulator of TJ integrity, is diminished in aged females and dramatically upregulated by estradiol, and may underlie the gender difference of BBB integrity after LPS-induced inflammation (Maggioli et al., 2016)
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It has been found that MnO 2 nanostructures would be decomposed by reaction with either H + or glutathione (GSH) existing within the TME, generating Mn 2+ ions that are able to significantly enhance T1-magnetic resonance (MR) imaging contrast for tumor-specific imaging and detection 25,26,27,28
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