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The intrinsic net charge and isoelectric point of Dihexa heavily influence its solubility profile across varying pH gradients in experimental buffers, complemented by molecular docking simulations that demonstrate optimal geometric fit within the active binding pockets of targeted mammalian receptor proteins, while the inclusion of specific stabilizing amino acid substitutions successfully reduces susceptibility to oxidative damage and enzymatic cleavage
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43 In a mouse model of T-cell-induced acute diarrhea, epithelial barrier dysfunction was associated with an abrupt increase in phospho (P)-MLC expression
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