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Figure 5 depicts the most common hepatic disposition models utilized for clearance predictions, including the well-stirred model, the parallel tube model, and the dispersion model, as well as the mathematical relationships that relate entering drug concentration ( C in ), exiting drug concentration (C out ), and Q H to total clearance CL H for each model
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In normal condition, GSK-3β enzyme is involved in glycogen metabolism, cell cycle regulation and cell proliferation
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