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applied Que in NAFLD model in vivo and vitro and showed a significant decrease in serum transaminase levels, a recovery for liver superoxide dismutase, catalase and GSH levels, and a relieve in lipid accumulation (76)
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The resulting model establishes a mechanistic cascade associating dietary triggers (gluten), intestinal injury (malabsorption), metabolic disruption (folate/MTHFR deficiency) and epigenetic dysregulation (SAM/DNMTs imbalance)
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