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35 Since then, various approaches for synthesizing acetylsalicylic acid have been explored, including the use of solid acid catalysts such as nanocrystalline sulfated zirconia 36 and the reaction between o-hydroxy salicylic acid and acetyl chloride

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This enzyme is inducible, meaning that it is not normally detected in most tissues, but its production can increase in response to certain stimuli, such as inflammation [237]