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VSMCs secrete extracellular matrix and form protective fibrous caps over advanced atherosclerotic lesions, which maintain plaques, prevent rupture, and reduce clinical atherothrombosis and acute cardiovascular and cerebrovascular events [129]

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→ Mechanism of Action → Binds to ghrelin receptors (GHS‑R1a) in the hypothalamus → Stimulates the pituitary gland to release growth hormone → Increases circulating levels of IGF‑1 , a powerful anabolic hormone → Enhances deep sleep stages and GH pulsatility over time → Works systemically with no injection required “MK‑677 increases serum GH and IGF‑1 levels to those seen in young adults, supporting muscle growth and improved body composition.” — Smith et al., The Journal of Clinical Endocrinology & Metabolism → Applications → Muscle preservation and hypertrophy → Improved sleep, recovery, and GH output → Long-term fat loss and recomposition → Off-cycle muscle retention → Age-related GH decline or recovery support → Delivery → Taken orally (10–25 mg/day) → Long half-life (~24 hours) allows once-daily dosing → Typically cycled for 8–12 weeks , or used continuously at low doses CJC‑1295 Overview and How It Works CJC‑1295 is a synthetic growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to increase natural growth hormone (GH) secretion