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The addition of homocysteine causes some proteins to become pro-inflammatory or pro-thrombotic.[ref] Oxidative stress, ER stress, and mitochondrial dysfunction: High homocysteine levels are also associated with increased oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress

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COCs were transferred to IVF medium (SAGE, CooperSurgical, Trumbull, CT, United States) and incubated at 37°C, 7% CO 2 and 5% O 2 for up to 4 h before insemination