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Dapsone in combination with doxycycline (2-drug combo) was more effective than dapsone alone, and dapsone + doxycycline + rifampin (3-drug combo) was more effective than the 2-drug combination

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Levels of active G6PD are regulated at both the transcriptional level via various canonical signaling pathways (e.g., JAK-STAT, Wnt, mTOR), and at the post-translational level (e.g., via phosphorylation, de-acetylation), allowing tight coordination of G6PD activity to meet acute cellular demand in response to oxidative stress, metabolic demand, or systemic inflammation ( Figure 1A-1 )