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Dry, or chapped, lips are a common nuisance rooted in the fact that lips lack oil glands, making them highly susceptible to moisture loss. A combination of environmental factors—like cold, wind, and

To overcome this challenge, efforts are being made to improve graft survival by co-transplanting with supportive cell types or neuroprotective agents [132] or employing functionalized composite scaffolds, such as those employed in mouse models of PD [133]

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249,250 These observations suggest that the nucleolus is a conserved stress signaling hub in times of water limitation, and highlight the potentially complex contributions from abiotic (e.g., changing component concentration) and biological (i.e., transcriptional shut-down) events to its remodeling