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It is represented by diverse clinical features impacting multiple organs, combined with a wide range of hematological and serological abnormalities, and disease comorbidities (Figure 1) ( Figure 1 Immune homeostasis is vital for the balance of immune activation and suppression across tissues and organs to prevent damage due to excessive, malfunctioning, and/or self-targeting immune responses (Table 1) contributes to maintaining homeostasis through their roles- within cellular transport, nutrient exchange, and waste removal as well as their roles directly within immunity through the identification and presentation of antigens, regulation of inflammation, and adhesion of leukocytes (Supplementary Table 1) ( Table 1 Consensus nomenclature and common names of scavenger receptors