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Although loss of ATP7B forces hepatic cells to defend against excess Cu by downregulating the high-affinity transporter CTR1 39 (see also Supplementary Fig
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213 Additionally, miR-224-3p downregulation under hypoxic GBM conditions reduces autophagy by targeting ATG5 and FAK family kinase-interacting protein of 200 kDa (FIP200), linking miRNA regulation to tumor metabolism
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