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Mitochondrial energy production also generates reactive oxygen species
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Interestingly, subcutaneous administration of ganaxolone, a β-methylated analogue of allopregnanolone, in preterm guinea pigs protected against the loss of myelination, hyperactive behavior and the premature mortality observed in untreated preterm control animals, highlighting the neuroprotective potential of allopregnanolone in mitigating neurodevelopmental disorders associated with preterm births [194]
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