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Glutathione metabolism in mitochondria. GS = glutathione, GS-T =... | Download Scientific Diagram
Next to the 6-OHDA model (168), one of the most often used PD models is induced by MPTP delivery (169), which persists extensively in the SN and results in PD symptoms with inhalation and cutaneous contact (169)
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Consistent with this model, genetic or pharmacological interventions that limit the generation of peroxidation-prone phospholipids reduce ferroptosis sensitivity, whereas inhibition of lipid peroxide detoxification promotes cell death [76-78]
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