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Recent studies demonstrate that curcumin significantly downregulates miR-21 (oncomiR suppression) while upregulating miR-34a/b/c by two- to four-fold in colorectal cancer cells ( p = 0.002), miR-138 ( p = 0.024), and miR-16 ( p = 0.0001) in human subjects, demonstrating systemic miRNA modulation ( Resveratrol targets the miR-200 family and miR-125b-5p for epithelial–mesenchymal transition (EMT) inhibition

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Furthermore, after transfer into LLC1-OVA tumor–bearing mice, the greatest numbers of IFN-γ–producing intratumoral CD8 + T cells were observed in mice that received A2ARi-treated GCLC-overexpressing CD8 + T cells (Figure 2P) accompanied by a decrease in tumor burden compared with other groups of mice (Figure 2Q)