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Inside the Science of AOD 9604: A Lipolysis Peptide
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23,24 Phenotypically modified VSMCs can produce a large number of extracellular matrix (ECM) proteins (such as elastic fibers, collagens, proteoglycans, and MMPs), and secrete a wide range of cytokines (MCP-1, IL-1β, and IL-6) that can regulate the function of neighboring cells in a paracrine manner, and release various extracellular vesicles (EVs) to induce vascular calcification
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