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865 The increased expression of SIRT1 similarly reduced acetylation of PGC-1α and FoxO1, which was associated with attenuation of high fat diet-induced mitochondrial dysfunction, insulin resistance, and obesity
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However, the rewiring of Gln metabolism can also promote the development of cardiovascular disease by fueling the Krebs cycle and stimulating the unrestrained growth and migration of vascular cells and the deposition of extracellular matrix
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