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Antifibrotic and signaling pathway-targeted strategies Renin–Angiotensin–Aldosterone System (RAAS) inhibitors The renin–angiotensin–aldosterone system (RAAS) contributes to radiation-induced injury by enhancing oxidative stress, promoting fibroblast activation, and stimulating TGF-β signaling
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As do other NO-donating compounds, GSNO induces oxidative stress and initiates apoptosis (Turchi, 2006)
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