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DEL7 and its analogs specifically inhibit coronavirus 3CL proteases Selectivity is considered a major challenge for targeting SARS-CoV-2 proteases for the treatment of COVID-19, as reported 3CL protease inhibitors, including GC376, are also potent inhibitors of human cathepsin L and B 17

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Increasing concentrations of cGMP within the smooth muscle cells activate protein kinase G, which ultimately reduces intercellular calcium concentrations, relaxes smooth muscle cells, and dilates associated blood vessels (Lincoln et al., 2001)