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Frontiers | Hyperbaric oxygen therapy and N-acetylcysteine: a redox-dependent interaction

Recent studies on a rat model have shown that a high-fat diet significantly increases TSH levels and causes thyroid dysfunction, suggesting that excessive consumption of animal fat induces thyroid dysfunction and may contribute to the pathogenesis of hypothyroidism [145,146]

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These arguments demonstrate that models of the methionine cycle need to be examined in greater detail to determine if (i) GSH does indeed accumulate under vitamin B 12 deficiency, (ii) if it does, how does vitamin B 12 —deficiency induced hyperhomocysteinemia affect GSH levels