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Full article: Leukotriene pathway in sickle cell disease: a potential target for directed therapy
Third, most mechanistic studies are based on animal models, while pharmacodynamic and metabolic differences in humans remain unclear, and the absence of clinical validation limits translational value
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Increased expression of FATP1 has been associated with insulin resistance, with a negative correlation between SLC27A1 (the gene encoding FATP1) expression and body mass index in humans [20, 28]
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