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Finally, a phase II front-line study (S9912) has been recently conducted by the Southwest Oncology Group, which investigated the addition of intravenous (iv) PLD (30 to 40 mg/m 2 , day 8, × 2 cycles) to intraperitoneal (ip) CDDP (75 mg/m 2 , day 2, every 21 days), and both iv and ip paclitaxel (135 mg/m 2 , day 1, every 21 days, and 60 mg/m 2 , day 8, every 21 days, respectively).93 This regimen gave clinical outcome measures similar to those reported in comparable patient populations treated with classical CDDP-containing combinations

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