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Additionally, oxidative stress and ROS can originate from xenobiotic bioactivation by prostaglandin H synthase (PHS) and lipoxygenases (LPOs) or microsomal P450s which can oxidize xenobiotics to free radical intermediates that react directly or indirectly with oxygen to produce ROS and oxidative stress [26] as in Fig (2)
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The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology
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