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Find out more about missed or delayed doses Subcutaneous EPKINLY is designed to improve tolerability and accessibility across practice settings 1-4 Step-up dosing of EPKINLY is intended to increase tolerability and mitigate incidence and severity of CRS Initiate treatment with the EPKINLY step-up dosing schedule and premedicate before each dose in cycle 1 to reduce the incidence and severity of CRS Provide Pneumocystis jirovecii pneumonia prophylaxis during treatment with EPKINLY and consider providing prophylaxis against herpesvirus during treatment with EPKINLY to prevent herpes simplex and herpes zoster Subcutaneous administration allows more gradual increases and lower peaks in plasma cytokine levels than IV administration 2,4 EPKINLY is an off-the-shelf treatment, available to treat patients at the moment of relapse Missed or delayed dose Restarting therapy after dosage delay 1 Last dose administered Time since last dose administered: More than 8 days Action for next dose(s)*: Repeat 0.16 mg, Administer 0.8 mg the following week, Followed by 2 weekly doses of 48 mg, Resume planned dosage schedule beginning with day 1 of the subsequent cycle *Administer pretreatment medication prior to EPKINLY dose and monitor patients accordingly

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