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Cognitive peptides in research: Semax, Selank, Dihexa and the new generation of peptide nootropics
Complex in vivo pharmacokinetic and pharmacodynamic hurdles The physicochemical properties and selectivity limitations of PROTACs manifest as highly complex pharmacokinetic (PK) and pharmacodynamic (PD) behaviors in vivo, leading to a nonlinear relationship between drug exposure and therapeutic effect that significantly undermines clinical predictability [65, 105]
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