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Optimizing glutathione status to tame autoimmunity - ThyroSisters

Therefore, we hypothesized that these five hub genes are important immune-related biomarkers for SLE

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However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines