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These effects can be possibly mediated via that prejunctional somatostatin sst 4 [72] receptor, whose stimulation produces the inhibition of the release of the proinflammatory neuropeptides, such as substance P and calcitonin-gene-related peptide (CGRP), from the peripheral terminals of capsaicin-sensitive sensory nerve endings [73,74]

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No published human pregnancy trials exist, so most clinicians recommend avoiding non-essential use unless your provider says otherwise