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Ultimately, it was revealed that cholinergic fibers are present within the subchondral bone of individuals with OA, and the release of acetylcholine (Ach) triggered by vagus nerve stimulation plays a prominent role in combating inflammation across various diseases while also providing pain relief
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The relationship between E-I balance and the presence of SOR suggests that interventions that boost GABAergic tone and/or reduce glutamatergic excitation may reduce the intensity of SOR
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