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A systematic review[5] of 18 randomized controlled trials involving 2,939 men and another analysis of 21 clinical trials involving 3,000 men and reviewed by Cochrane[6] support the safety and efficacy of saw palmetto extract preparations, and animal and human clinical trials continue to support a role for saw palmetto in prostate health.[7-10] Mechanisms of action have not been fully elucidated, but there is evidence that saw palmetto inhibits 5-alpha reductase (5AR)—the enzyme that reduces testosterone to the more potent androgen dihydrotestosterone (DHT).*[11,12] Other effects have been proposed, including that saw palmetto prevents DHT from binding to androgen receptors, has antiestrogenic and antiproliferative effects, inhibits growth factors, affects alpha-1 adrenoceptors and 1,4- dihydropyridine receptors, and helps maintain healthy fluid balance in prostate tissues.[7,12-15] Andro Synergy™ features a high-quality, standardized (85% free fatty acids) extract to assure the opportunity for the best clinical outcomes.* Pygeum Africanum The use of pygeum dates back approximately 300 years, and extracts are a well-known and often-used alternative for supporting prostate health in many European countries.[16] Numerous open and placebo-controlled studies in large populations have demonstrated its efficacy and acceptability for supporting healthy urine flow and volume, reducing nocturnal voiding, and improving quality of life.[17-21] Multiple mechanisms of action have been proposed for the genitourinary effects of pygeum, which contains numerous beneficial constituents, such as beta-sitosterol