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In each of these states, CD38 upregulation is accompanied by depletion of NAD + , which leads to impaired function of important NAD + -dependent enzymes resulting in cellular metabolic collapse 22
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SLC25A11 belongs to the solute carrier family 25 (SLC25), which encompasses 53 known carrier proteins that play critical roles in regulating cellular metabolism and physiological processes (reviewed in Kunji et al., 2020)
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