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Warnings: Patients with early Leber's disease (hereditary optic nerve atrophy) may experience severe and rapid optic atrophy when treated with vitamin B12. Additionally, treating severe megaloblastic anemia with vitamin B12 can lead to fatal hypokalemia due to increased erythrocyte potassium requirements
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5 , 6 Soon thereafter, the worldwide distribution of G6PD deficiency became apparent, and the variation of clinical expression of enzyme deficiency was discovered
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