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The transcription factor Nrf2, often constitutively activated in cancers, drives the expression of antioxidant genes (HO-1, NQO1) and detoxifying enzymes, creating a buffer against ROS overload
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Besides the cyclooxygenase pathway, the other major metabolic fate of arachidonic acid is the lipoxygenase pathway, which leads to the formation of leukotrienes and lipoxins
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