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Yijun Bao, [email protected] † These authors have contributed equally to this work and share first authorship This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Metformin (N,N-dimethylbiguanide), a standard clinical drug for type 2 diabetes mellitus (T2DM) for over 60 years (Foretz et al., 2023), has been shown to have multiple biological effects beyond its hypoglycemic properties, such as antioxidant, anti-inflammatory, anti-tumor, anti-fibrotic, and antiviral activities (Du et al., 2022

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