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Frontiers | Targeting the NRF2 pathway for disease modification in neurodegenerative diseases: mechanisms and therapeutic implications

Clinical evidence on antioxidant use in preeclampsia The use of antioxidants as adjuvant therapy has shown favorable effects in conditions associated with increased OS, such as type 2 diabetes and metabolic diseases, including obesity, where supplementation has been linked to the attenuation or delayed progression of complications 33

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Additionally, they question the utility of the β 2 M endpoint as a basis to define a permissible exposure level for Cd and its toxicity threshold level, given that a low eGFR is a pathological sign for the diagnosis of chronic kidney disease (CKD) [2]