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The 5-HTP/TRP ratio was significantly lower in patients (p = 0.017) ( Figure 3 ), supporting our previous findings of redirecting TRP catabolism to the kynurenine pathway
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The design of a ligand requires several steps to fulfil [2]: Determination of the binding site or possible biological interactions to use as a template for the modelling, Initial design of the ligand using this template, Preparation of a ligand library and chromatographic evaluation, Selection of the ligand of interest, Optimisation and chromatographic evaluotion of the adsorbent following the immobilization
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