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In contrast, mutations in the PKC phosphorylation sites in the C-tail gave rise to “PKC-site mutants,” which demonstrated partial impairment in sequestration and endocytosis but completely diminished downregulation, indicating an important role for PKC in this process (Prinster, 2003)

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17 In this trial, muscle RNA sequencing (RNA-seq) showed the activation of mitochondrial gene sets specifically at the UA 500 mg dose