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The opioid story is genuinely mixed: some antinociceptive models show naloxone-sensitive effects, others show analgesia that is naloxone-insensitive, and in-vitro work reports no direct opioid receptor binding but increased met-enkephalin release
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Transdermal cortisol measurements have been demonstrated using iontophoretic extraction, MN-assisted sampling, and electrochemical platforms employing affinity receptors or MIPs
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