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Curiously, gene expression of NRT1.1 and NRT2.1 transporters is constitutively upregulated in roots of nia1 nia2 plants, suggesting that NR activity or a nitrogen-containing metabolite derived from nitrate reduction feedback regulate uptake systems 15
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In a preclinical study to investigate ATZ’s cardiotoxicity, rats orally exposed to ATZ dissolved in corn oil (to mimic human exposure) at 400 mg/kg per day for three weeks exhibited symptoms of oxidative stress in the heart and decreased GSH levels (70)
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