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In HTG-AP, hydrolysis of triglyceride-rich lipoproteins and peripancreatic fat generates excessive amounts of non-esterified fatty acids (NEFAs), particularly unsaturated long-chain fatty acids, which exceed the buffering capacity of LDs and promote mitochondrial depolarization, Ca 2+ dysregulation, oxidative stress, and necrotic cell death (61)
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All evaluations were conducted following the guidelines for human research established by the Ethical Committee of the College of Pharmacy, Qassim University, and The Research Ethics Committee at the Ministry of Health for Saudi Arabia
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