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Interestingly, these ERR α -null mice also display reduced muscle oxidative capacity, an effect that is also induced by C29, a synthetic ERR α inverse agonist (Patch et al., 2011) These contradictory effects, at least in terms of a potential treatment of metabolic diseases, are also aggravated by the potential for an ERR α inverse agonist to induce heart failure (Huss et al., 2007)
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