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doi: 10.1016/j.ergon.2015.10.004 [DOI] [Google Scholar] 6

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The reducing equivalents required for this reaction are supplied by NADPH, generated through the pentose phosphate pathway within the RBC ( In vitro experiments have shown that shear stress increases phosphorylation at Ser1177 on eNOS, a known activation site, and leads to elevated NO production (Nagarajan et al., 2016)