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In addition, the roles of TNF-α and IFN-γ were determined when peripheral blood mononuclear cells (PBMC) isolated from MS patients secreted significant amounts of them [56–61]

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The 2025 narrative review titled “Regeneration or Risk?” , published in Current Reviews in Musculoskeletal Medicine , is blunt about it: the authors found only three pilot human studies in the entire literature, and concluded that BPC-157 “should be considered investigational, and its use approached with caution.” The 2025 HSS Journal systematic review adds two further points of context — BPC-157 lacks United States Food and Drug Administration approval, and it is banned in professional sport