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The pharmacological effects of metformin have been shown to target the insulin-like growth factor (IGF), AMP-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K)/AKT, MAPK, NF-κB, and other signal transduction pathways, highlighting its potential in the treatment of gynecological disorders
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Zhao et al (184) found that AF can markedly inhibit α-SMA overexpression and FN deposition in the livers of rats treated with BDL and HSC activation and collagen I and III synthesis are also markedly inhibited by coadministration
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