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In vitro studies have shown that PROTAC 22 , which results from the attachment of pomalidomide via an alkyl linker to the AT13387 inhibitor derivative, selectively degrades HSP90Ξ± compared with other isoforms, with a degradation potency in the micromolar range (half-maximal target degradation (DC 50 ) value of 0.295 ΞΌM, D max = 66.4%)
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