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CoQ10, another exogenous antioxidant reduced by FSP1, has shown limited clinical efficacy in NDDs.In a Phase III trial (NCT00740714), oral CoQ10 at 1200 or 2400 mg/day, combined with 1200 IU/day of vitamin E, did not slow PD progression, as UPDRS scores increased similarly across all groups (Beal et al., 2014)

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These receptors contain specialized substrate-binding modules (SBMs) that interact with the N-terminal domain of cullin proteins (31)