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RSL3 binds to the nucleophilic active site of GPX4, and then reduces the expression level of GPX4 most effectively through chloroacetamide moiety (Jelinek et al., 2018), thus inactivating GPX4, producing lethal ROS accumulation and inducing ferroptosis

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Both IFN-γ and TNF-α are key players in the induction of cell-mediated immunity and granuloma formation to effectively control an M