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Many studies have clearly demonstrated an increased incidence of oxidative damage either from reactive oxygen species (ROS) or peroxides in other neurological diseases including Parkinson’s 14 , Huntington’s 15 , Alzheimer’s 16 , and Amyotrophic Lateral Sclerosis (ALS) 17

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Similarly, in protoplasts, VSRs exclusively co-localizes with MVBs labeled by ARA7 and RABG3f, and do not overlap with other organelles such as the ER, Golgi apparatus, or TGN (Supplementary Fig