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In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintide–semaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results
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In cultures of primary osteoblasts or osteogenic cell lines, IGF-I treatment promotes cell proliferation, differentiation and matrix production (54), and inhibits their apoptosis (55,56)
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